Tissue-specific nuclear architecture and gene expession regulated by SATB1
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چکیده
منابع مشابه
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متن کاملThe matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression.
The nuclear matrix has been implicated in several cellular processes, including DNA replication, transcription, and RNA processing. In particular, transcriptional regulation is believed to be accomplished by binding of chromatin loops to the nuclear matrix and by the concentration of specific transcription factors near these matrix attachment regions (MARs). A number of MAR-binding proteins hav...
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متن کاملPhosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.
Special AT-rich sequence-binding protein 1 (SATB1) is a tissue-restricted genome organizer that provides a key link between DNA loop organization, chromatin modification/remodeling, and transcription factor association at matrix attachment regions (MARs). The SUMO E3 ligase PIAS1 enhances SUMO conjugation to SATB1 lysine-744, and this modification regulates caspase-6 mediated cleavage of SATB1 ...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2003
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng1146